Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types.

  • Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases
  • Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction

Chemistry of Nitric Oxide: Biologically Relevant Aspects. Reactions Between Nitric Oxide, Superoxide, And Peroxynitrite: Footprints of Peroxynitrite in Vivo. Oxygen Radical-Nitric Oxide Reactions in Vascular Diseases. Nitric Oxide Synthases: Gene Structure and Regulation. Transcription of the Human Neuronal Nitric Oxide Synthase Gene in the Central Nervous System Is Mediated By Multiple Promoters. Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase. Regulation and Function of Inducible Nitric Oxide Synthases in Various Cell Types. Control and Consequences of Endothelial Nitric Oxide Formation. Control of Electron Transfer in Neuronal Nitric Oxide Synthase By Calmodulin, Substrate, Substrate Analogs, And Nitric Oxide. Negative Modulation of Nitric Oxide Synthase By Nitric Oxide and Nitroso Compounds. Regulation of Nitric Oxide Synthase: Role of Oxygen-Radicals and Cations in Nitric Oxide Formation. Why Tetrahydrobiopterin? Nitric Oxide and Cyclic GMP Signaling. Nitric Oxide and Intracellular Heme. High Level Expression of Biologicall Active Solube Guanylyl Cyclase Using the Baculovirus System Is Strongly Heme-Dependent. Cgmp Signalling Through Camp- And Cgmp- Dependent Protein Kinases. Physiological and Toxicological Actions of Nitric Oxide in the Central Nervous System. Chemistry, Biochemistry, And Biological Actions. Glyceraldehyde-3-Phosphate Dehydrogenase: A Target for Nitric Oxide Signaling. Nitric Oxode Donors: Biochemical Pharmacology and Therapeutics. Nitric Oxide Donors: A Continuing Opportunity in Drug Design. Nitric Oxide and Peripheral Adrenergic Neuromodulation. A Study on Tumor Necrosis Factor, Tumor Necrosis Factor Receptors, And Nitric Oxide in Human Fetal Glial Cultures. Inhaled Nitric Oxide, Clinical Rationale, And Applications. Inhaled Nitric Oxide Therapy of Pulmonary Hypertension and Respiratory Failure in Premature and Term Neonates. Clinical Applications of Inhaled Nitric Oxide in Children.

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